Special new post coming soon…keep an eye on http://www.brsmblog.com 😛
UPDATE New guest post on BRSM Blog: Unnatural Products 4: Tetrahedrane
It’s been far too long since my last post but I feel its just that time of year. I’ve noticed that posts have slowed at other blogs I follow as well (and around this time last year my posts were down). March and April seem to be very busy for chemists. For me, the lack of free time can be attributed to a number of factors. Since I’m a TA I’ve been seeing a lot more students because of mid-term preparation. Next, I plan on attending two conferences (one of which I’ve mentioned, the CGSS in Buffalo, the other being the ACS meeting in Philly in August) which required abstracts. Lastly, we are coming to a close on a couple of projects meaning we need to prepare supporting information, tighten up manuscripts, and start sending stuff out. Plus, our walk-on 300 MHz NMR went down for all of this past week and the week before. If one NMR goes down, it really becomes a headache with only two to bear the load of both the chemistry department and the school of pharmacy. Add to the mix that I have not encountered any really grabbing papers lately and you can see why posts are down. So what’s been going on in the Leadbeater lab since my last post? Well, as I mentioned, I sent my abstract in for the ACS meeting in Philly. I will be presenting (if I get accepted) on the work we’ve done with Professor Tilley (which I will also do at the CGSS). We finished writing the last two labs for the organic lab course. We are having them do a hydrogenation and a LiAlD4 reduction of ethyl cinnamate to show them not only that you can do reductions selectively but to give them exposure to working with gases as well as working with deuterated compounds. In other news, since projects have been winding down, I’ve been trying to come up with some more (mostly ones related to oxoammonium salt chemistry) and I’ve had some luck so far and I think I might be close to something good…maybe :). We hope to have our collaborative work with Dr. Tilley done by June and hence much of my focus (and Mike’s) has been on that. Our most recently flow paper has been accepted to OPRD pending revisions, so I spent a little time working on those as well recently. Now that you know pretty much my whole life for the past few weeks 😛 let’s get to the lit.!
This week’s article comes from Floreancig group at the University of Pittsburgh and it involves (as you might have guessed) organosulfur chemistry. The Floreancig is a typical organic group (doing both total synthesis and methodology development). They specialize in oxidative C-C and C-H bond activation for novel transformations. DDQ, or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, is their reagent of choice for facilitating this sort of activation. Until recently, Floreancig has exploited these oxidative activations for the chemoselective preparation of oxygen containing heterocycles such as pyranones. The general idea can be seen below:
Overall, while sulfur isn’t really my cup of tea, I really enjoyed this article. What can be better than carbocations, cyclizations, and silicon right? I hope you enjoy this article as much as I did and hats off to the Floreancig group for a job well done! That’s it for this week…Ckellz…Signing off…